White rot basidiomycetes are known to degrade recalcitrant pollutants that pose serious risks to the environment and health. We compared the biodegradability of Aroclor 1248 by four different white-rot fungi and examined the effects of byproducts produced by the fungi. The biodegradation of Aroclor 1248 was determined via gas chromatography, and enzyme activity was measured via an enzyme assay. We found that Phanerochaete chrysosporium and shiitakes were effective bioremediators of Aroclor 1248 in contaminated substrate.